Robison Funding Sources

NIMH R01 MH111604
The proposed work seeks to delineate the role of gene transcription and cell physiology of hippocampal neurons that project to specific brain targets in resilience to stress. This work utilizes innovative techniques to uncover basic pathophysiology that may be exploited as novel therapeutic interventions in major depressive disorder or posttraumatic stress disorder.

NIAID R01 AI168014
The proposed work will uncover the specific mechanisms by which ΔFosB regulates MC function in vivo as well as the key transcriptional targets of ΔFosB in MCs that may act as molecular handles for therapeutic intervention in MC-related diseases or infection.

NICHD R01 RHD072968D
This is a collaborative five-year R01 with Dr. Adam Moeser at MSU to investigate the role of mast cells in modulating the impact of early life stress on adult gastrointestinal health. The Robison laboratory provides mouse behavioral models, epigenetic and transcriptional expertise, and integration of the gut-brain axis. Results of this work will inform our understanding of the role of the immune system in mediating the effects of childhood stress on physiology and health throughout life.

NIDA R01 DA040621
The goal of this project is to generate potent probes to target ΔFosB in vivo, which will enable us to test the therapeutic potential of ΔFosB as a novel target to treat drug addiction. In addition, we will be able to test a deeply innovative strategy that uses ΔFosB as a conduit to selectively regulate key strategic target genes in very select regions of the brain.

NIMH R01 MH135937
This grant investigates circuit-specific androgen receptor function in development in the California mouse. The Robison lab provides electrophysiological characterization of hippocampal neurons in Peromyscus (California mice) with manipulation of androgen signaling during development.

NIMH R01 MH130544
To understand the epigenetic mechanisms underlying ASH1L’s function in ASD pathogenesis, we will use an Ash1l-knockout-induced ASD mouse model to examine the function, transcriptome, and epigenome of cortical excitatory neurons, inhibitory neurons, and astrocytes in the mouse brain. The Robison lab will contribute electrophysiological and behavioral analyses of ASH1L mutant mice.

NIMH F31 MH134532
This is an individual NRSA F31 Award to my senior student, Ms. Chiho Sugimoto, that funds her thesis research on the role of androgen receptors in hippocampal circuit excitability.

NIMH R01 MH135937
The major objective of this grant is to uncover the mechanisms by which oxytocin differentially modulates the mesolimbic dopamine system and the BNST to regulate social approach vs social anxiety. The Robison lab will contribute electrophysiological analyses of these neural circuits using novel viral vectors to isolate oxytocin neurons and signaling.